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Hakim Sabzevari University
Roya Askari, PhD
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Showing 4 results for Bdnf

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Volume 3, Issue 6 (10-2011)

Hamzeh Bayani, Ziya Fallah Mohammadi, Mohammad Fazelzadeh,
Volume 6, Issue 11 (3-2014)

Purpose: Cortisol and BDNF are two factors that affect the human brain neurogenesis. The purpose of this study was to comparison the effect of two exhaustive aerobic and anaerobic physical activity on serum BDNF and cortisol levels and their relationship together in active men. Material and Methods: 16 active students divided into two groups randomly. Tests used in this study consisted of Cunningham and Faulkner test for anaerobic group and Astrand test for aerobic group. blood sample was taken before and immediately after exhaustion. Results: T-test results showed that both acute exhaustive anaerobic and aerobic exercise increases significantly BDNF level (P<0/05). Also, Serum cortisol levels following Implementation of aerobic and anaerobic exercise to exhaustion decreased significantly (P<0/05) and increased non significantly (P>0/05), respectively. There was no significant correlation between cortisol and BDNF levels in the two groups. Likewise, independent samples t-test showed no significantly different between aerobic and anaerobic groups in BDNF and COR levels. Conclusion: The present results indicate exhaustive aerobic and anaerobic exercise had significant and positive impact on serum BDNF. Due to the lack of correlation between these two factors can be stated that probably run acute aerobic and anaerobic activity is not increased COR to the extent that suppresses BDNF levels in active individuals, therefore is not a threat to the health of the nervous system.
Azadeh Hosseini, Abdolhossein Parnow, Mohammad Reza Zolfaghari , Issac Karimi, Seyedeh Azadeh Hosseini,
Volume 7, Issue 14 (10-2015)

Introduction: Brain‐derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family that plays key roles in regulating survival, growth and maintenance of neurons. Plasma BDNF is thought to help in the adaptation to the exercise; however, the effects of exercise interventions on BDNF are not well understood. Thus, the purpose of this study was to examine the effect of acute resistance training on plasma BDNF in rats.
Methods: Twenty five female Wistar rats were selected and divided randomly into control and resistance training groups. Ladder climbing while carrying weights was considered as resistance training task. Each session contained three sets of training with five repetitions. In group resistance training, 24, 48 and 72 hours after the exercise, the animals were anesthetized and blood samples were taken. In order to evaluate BDNF content, ELISA kit method was employed and for the statistical analysis, ANOVA test with the help of SPSS  software (Version 18) were used. The significant level was set at P<0.05.
Results: Results showed that in comparison to the control group, plasma BDNF levels in the members of the training group increased significantly immediately 24 and 72 h after exercise (p=0.001, p=0.09 and p=0.027, respectively).
Conclusions: It could be concluded that resistance training affects plasma BDNF. Thus, resistance exercise could be considered as one of the proper models to examine the molecular behavior of this neurotrophin.
Keywords: resistance training, plasma BDNF, Wistar rat.

Ms Tahereh Dalir, Mister Reza Gharakhanlou, Mister . Maghsoud Peeri, Mister Hassan Matin Homaee,
Volume 19, Issue 19 (3-2018)

Introduction: Exercise through BDNF induces its beneficial effects on the brain. However, its cellular mechanisms are not fully understood. Thus, the purpose of this study was to investigate the effect of 8 weeks interval aerobic training on mRNA expression of SIRT1, CREB and BDNF genes in the hippocampus of male Westar rats.
Methods: Twelve 8 week old rats were the subjects of this study rats were randomly divided into two groups: exercise group and control group animals in the exercise group experienced interval aerobic exercise for 8 weeks (5 sessions per week at a speed of 10 to 15 m/min). Forty-eight hours after the last training session, animals were sacrificed and hippocampal tissue was extracted. mRNA expression of SIRT1, CREB and BDNF genes was determined by the real-time PCR method. An independent t-test was used to compare groups and significant differences were considered at the P≤0.05 level.
Results: The results showed that the expression of SIRT1, CREB and BDNF mRNA levels in hippocampal tissue of the exercised group were significantly increased (P ≤0.001).
Conclusion: Overall, it appears that interval aerobic exercise is able to upregulate brain BDNF levels through the SIRT1/CREB/BDNF signaling pathway hence, this type of exercise training can be used to induce the beneficial effects of exercise on brain health.

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