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Hakim Sabzevari University
Roya Askari, PhD
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Showing 3 results for Peeri

Ms Tahereh Dalir, Mister Reza Gharakhanlou, Mister . Maghsoud Peeri, Mister Hassan Matin Homaee,
Volume 19, Issue 19 (Volume 19, Number 1, 2018 2018)

Introduction: Exercise through BDNF induces its beneficial effects on the brain. However, its cellular mechanisms are not fully understood. Thus, the purpose of this study was to investigate the effect of 8 weeks interval aerobic training on mRNA expression of SIRT1, CREB and BDNF genes in the hippocampus of male Westar rats.
Methods: Twelve 8 week old rats were the subjects of this study rats were randomly divided into two groups: exercise group and control group animals in the exercise group experienced interval aerobic exercise for 8 weeks (5 sessions per week at a speed of 10 to 15 m/min). Forty-eight hours after the last training session, animals were sacrificed and hippocampal tissue was extracted. mRNA expression of SIRT1, CREB and BDNF genes was determined by the real-time PCR method. An independent t-test was used to compare groups and significant differences were considered at the P≤0.05 level.
Results: The results showed that the expression of SIRT1, CREB and BDNF mRNA levels in hippocampal tissue of the exercised group were significantly increased (P ≤0.001).
Conclusion: Overall, it appears that interval aerobic exercise is able to upregulate brain BDNF levels through the SIRT1/CREB/BDNF signaling pathway hence, this type of exercise training can be used to induce the beneficial effects of exercise on brain health.
Miss Soghra Sujodi, Dr. Maghsoud Peeri, Dr. Parvin Farzanegi, Dr. Maryam Delfan,
Volume 19, Issue 19 (Volume 19, Number 1, 2018 2018)

Introduction: Diabetic cardiomyopathy refers to changes in the heart as a result of altered glucose homeostasis, leading to ventricular dysfunction, and it is associated with mitochondrial abnormality. Since physical exercise has been known as cardioprotective, the aim of the present study was to investigate the effect of 6 weeks of resistance exercise preconditioning on mitochondrial fusion and fission processes in cardiac tissue of type 2 diabetic rats.
Methods: 18 male Westar rats were randomly divided into 3 groups: diabetes group (n=6), exercise + diabetes group (n=6) and control group (n=6); The exercise group performed resistance training (Carrying weights with 40 to 160 percent of body weight on the ladder) for 6 weeks and 5 sessions per week. To induce type 2 diabetes, a high-fat diet was administered concurrently with the start of the training program and continued until the end of the study, and 48 hours after the last training session, the injection of STZ was administered intraperitoneally at a dose of 25 mg/kg. Seven days after STZ injection, all rats were dissected and their left ventricular tissue extracted. Real-time-PCR was used to measure the mRNA expression of MFN-2, OPA-1 and Drp-1 genes. Statistical analysis was performed using one-way analysis of variance at a significance level of p ≤ 0.05.
Results: Decreased mRNA expression of MFN-2 and OPA-1 genes and increased mRNA expression of Drp-1 gene were observed in diabetic group animals compared to control ones (p ≥ 0.001). Also, trained diabetic rats showed higher MFN-2 and OPA-1 mRNA expression (p ≥ 0.001), and lower Drp-1 mRNA expression (p ≥ 0.01) compared to the diabetic group.
Conclusion: It seems that 6 weeks of resistance training preconditioning can reduce the risk of diabetic cardiomyopathy through the up-regulation of proteins involved in mitochondrial fusion and down-regulation of enhanced mitochondrial fission in the heart tissue.

Hojat Arab, Mohammadali Azarbayjani, Maghsood Peeri, Mohammadali Sardar,
Volume 21, Issue 21 (Volume 21, Number 1, 2019 2019)

Introduction and Purpose: Anaerobic power and capacity are considered determinants of performance and are usually assessed in athletes as a part of their physical capacities’ evaluation along the season. The purpose of this study was to evaluate the validity a new field test for the assessment of the anaerobic capacity of elite wrestlers.
Materials and methods: 42 elite wrestlers of Khorasan Razavi participated in this study, voluntarily. In two stages with one-week rest interval, an upper-body Wingate anaerobic test and a specifically designed test were measured. Before, immediately, five and ten minutes, variations of the heart rate and blood lactate were measured. In the designed test, a battle rope was used, each participant performed alternating arm waves with a Japanese guard for 30 seconds as maximum as possible.
To analyze of data Pearson correlation coefficient, inter-class correlation coefficient , Bland-Altman agreement and linear regression were used.
Results: There was a significant relationship between the anaerobic capacity of the 30-second upper-body Wingate test and the specifically designed test. Also, a significant relationship was observed between absolute (r=0.66; P=0.001) and relative peak (r=0.52; P=0.007), absolute mean power (r=0.44; P=0.02) and absolute minimum power (r=0.41; P=0.03) in two methods. The variations in HR and BLa were statistically significant at minute 5 (r=0.52; P=0.007) and 10 (r=0.65; P=0.001), respectively. The linear regression model was able to predict the anaerobic capacity using the specifically designed test. The inter-class agreement coefficient was poor (P=0.463), but my Bland-Altman diagram showed that there was a good agreement between the mean and the difference in anaerobic capacity in both methods.
Discussion and Conclusion: Using available alternative methods with high external validity to assess upper anaerobic capacity is a more appropriate method than laboratory tests. The specifically designed test seems to able the prediction of the upper body anaerobic capacity in elite wrestlers.

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