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Hakim Sabzevari University
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Showing 4 results for Gharakhanlou

Dr Mahdieh Molanouri Shamsi, Dr Mehdi Mahdavi, Dr Reza Gharakhanlou, Dr Mohammad Zohair Hassan,
Volume 6, Issue 11 (3-2014)

Introduction: It suggested that cytokines or other peptides that are produced, expressed and released by muscle fibres (usually during contraction) and exert endocrine effects should be classified as myokines. Many proteins produced by skeletal muscle are dependent upon contraction. Therefore, it is likely that myokines may contribute in the mediation of the health benefits of exercise. Our aim was to investigate effect of intensive resistance exercise training on protein expression of IL-6, IL-1β and TNF-α myokines in skeletal muscle in rats with diabetes. Materials and methods: Rats were divided into control, training, streptozotocin induced diabetic and diabetic training groups. Training groups performed for Resistance training consisted of climbing a 1 m ladder with increasing weight added to the tail. Protein expression of myokines in FHL skeletal muscle measured by ELIZA method. Results: The results of this study indicate that training and diabetes interaction was significant for IL-6 in FHL muscle (P<0.05). Also, tumor necrosis factor-alpha (TNF-α) and IL-1β levels were increased by diabetes, but not changed by training. Discussion and Conclusion: In conclusion, we found that in diabetic rats, resistance training decreased muscle IL-6 levels, and preserved FHL muscle mass. It is probably increased inflammatory cytokines in skeletal muscle with resistance training is a mechanism for skeletal muscle adaptation.
Mohammad Soleimanifarsani, Reza Gharakhanlou, Hamid Agha Alinejad, Ebrahim Banitalebi, Zahra Hemati Farsani,
Volume 6, Issue 12 (3-2015)

Abstract Background & purpose: The aim of present study was to examine the effect of resistance training on Sphingosine-1-phosphate (S1P) levels of plasma and cardiac muscle in male Wistar rats. S1P is a bioactive platelet-derived sphingolipid that is involved in regulation of proliferation, differentiation, Hypertrophy and anti-apoptosis of cells and activation of satellite cells. Materials & methods: Twenty four 8-week-old male Wistar rats were used in this study. The initial body weight of rats was 190–250 gr. All animals were maintained in pairs in an environmentally controlled room at 22°C, 12:12-h photoperiod cycle and allowed normal cage activity. The animals were fed standard rat chow and water ad libitum. After a week of acclimation to the animal facility, the rats were assigned randomly to a control (N=12) or training (N=12) group. Resistance training was done using a 1 meter height ladder with 2 cm grid with an 85 degree incline, and weights attached to rat's tails. The content of sphingosine-1- phosphate (S1P) present in the chloroform layer was determined by means of high performance liquid chromatography (HPLC). results: Resistance exercise training increased the total content of S1P in cardiac muscle (P=0.08) in comparison to control group. This increase was not significant, but was close to significance. The level of this factor was significantly increased in plasma following resistance training. Conclusion: According to structural and functional roles of this sphingolipid and because of its increase after resistance training, and as it is the first study in this area, future studies with different resistance training programs or higher number of subjects may show the accurate roles of this factor in heart muscle adaptation to increased level of activity.
Ms Tahereh Dalir, Mister Reza Gharakhanlou, Mister . Maghsoud Peeri, Mister Hassan Matin Homaee,
Volume 19, Issue 19 (Volume 19, Number 1, 2018 2018)

Introduction: Exercise through BDNF induces its beneficial effects on the brain. However, its cellular mechanisms are not fully understood. Thus, the purpose of this study was to investigate the effect of 8 weeks interval aerobic training on mRNA expression of SIRT1, CREB and BDNF genes in the hippocampus of male Westar rats.
Methods: Twelve 8 week old rats were the subjects of this study rats were randomly divided into two groups: exercise group and control group animals in the exercise group experienced interval aerobic exercise for 8 weeks (5 sessions per week at a speed of 10 to 15 m/min). Forty-eight hours after the last training session, animals were sacrificed and hippocampal tissue was extracted. mRNA expression of SIRT1, CREB and BDNF genes was determined by the real-time PCR method. An independent t-test was used to compare groups and significant differences were considered at the P≤0.05 level.
Results: The results showed that the expression of SIRT1, CREB and BDNF mRNA levels in hippocampal tissue of the exercised group were significantly increased (P ≤0.001).
Conclusion: Overall, it appears that interval aerobic exercise is able to upregulate brain BDNF levels through the SIRT1/CREB/BDNF signaling pathway hence, this type of exercise training can be used to induce the beneficial effects of exercise on brain health.
Mr Mehdi Madahi, Mr Reza Gharakhanlou, Mr Mohammad Ali Azarbayjani,
Volume 26, Issue 26 (Volume 26, Number 2, 2021-2022 2021)

Introduction and purpose: Decreased physical activity due to sciatic nerve ligation (SNL) cause muscle atrophy. The purpose of the present study was to investigate the effect of decreased physical activity in the form of spinal nerve ligation (SNL) on the expression of muscle atrophy-related genes (TWEAK and Fn14) after resistance, endurance and combined exercises.
Materials and Methods: Thirty rats were randomly divided into four groups: 1- Control group-SNL (Sham+SNL) (N=7),2- Mixed training group-SNL (Mix+SNL) (N=7), 3- Endurance training group-SNL (TE+SNL) (N=8), and 4- Resistance training group-SNL (LA+SNL) (N=8). Mix+SNL, TE+SNL and LA+SNL groups participated in training program for six weeks. Decreased physical activity was implemented for four weeks. Real time-PCR technique was used to measure gene expression. To determine the difference between research variables, analysis of variance, Tukey's post hoc test were used at a significance level of 0.05.
Results: The results showed that the gene expression of TWEAK and Fn14 increased by decreased activity. The expression of TWEAK in SNL+La and SNL+Mix groups was significantly lower than Sham+SNL group (P=0.001), and the expression of Fn14 was significantly lower only in the SNL+Mix group compared to the Sham+SNL group (P=0.003). However, there was no significant change in the expression of TWEAK and Fn14 genes in SNL+TE group compared to Sham+SNL group.
Discussion and Conclusion: These findings show that performing six weeks of resistance or combined training compared to endurance training before reduced activity (SNL), prevents the increase in the gene expression of TWEAK and Fn14. Therefore, the animals that included resistance training in their training program are more resistant to muscle atrophy caused by reduced physical activity than the group that only did endurance training.

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