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:: Volume 19, Issue 19 (2018) ::
2018, 19(19): 11-18 Back to browse issues page
Effect of 8 weeks aerobic training on SRT1, CREB and BDNF genes expression in hippocampus of Wistar rats
Tahereh Dalir, REZA Gharakhanlou *, . Maghsoud Peeri, Hassan Matin Homaee
Tarbiat Modares University
Abstract:   (3127 Views)
Introduction: Exercise through BDNF induces its beneficial effects on the brain. However, its cellular mechanisms are not fully understood. Thus, the purpose of this study was to investigate the effect of 8 weeks interval aerobic training on mRNA expression of SIRT1, CREB and BDNF genes in the hippocampus of male Westar rats.
Methods: Twelve 8 week old rats were the subjects of this study rats were randomly divided into two groups: exercise group and control group animals in the exercise group experienced interval aerobic exercise for 8 weeks (5 sessions per week at a speed of 10 to 15 m/min). Forty-eight hours after the last training session, animals were sacrificed and hippocampal tissue was extracted. mRNA expression of SIRT1, CREB and BDNF genes was determined by the real-time PCR method. An independent t-test was used to compare groups and significant differences were considered at the P≤0.05 level.
Results: The results showed that the expression of SIRT1, CREB and BDNF mRNA levels in hippocampal tissue of the exercised group were significantly increased (P ≤0.001).
Conclusion: Overall, it appears that interval aerobic exercise is able to upregulate brain BDNF levels through the SIRT1/CREB/BDNF signaling pathway hence, this type of exercise training can be used to induce the beneficial effects of exercise on brain health.
Keywords: SIRT1, CREB, BDNF, Hippocampus, Interval aerobic training
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Type of Study: Research | Subject: Special
Received: 2020/01/12 | Accepted: 2020/09/8 | Published: 2021/04/29
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dalir T, Gharakhanlou R, Peeri . M, Matin Homaee H. Effect of 8 weeks aerobic training on SRT1, CREB and BDNF genes expression in hippocampus of Wistar rats. Journal of Sport and Biomotor Sciences 2018; 19 (19) :11-18
URL: http://journals.hsu.ac.ir/sbs/article-1-846-en.html

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